[1] The district encompasses the former relocation center for Arkansans diagnosed with tuberculosis and an administration building built in the Art Deco style in 1909.

The facility became known worldwide as one of the most successful and modern hospitals for the treatment of tuberculosis of its day.

The sanatorium complex was self-sustaining, with dormitories, staff entertainment buildings, a chapel, laundry, dairy, water treatment plant, independent telephone system, and even a fire department.

With the introduction of more effective drug therapy, the patient population began to decline.

The campus was then used as the Booneville Human Development Center, a state-run residential program for adults with mild and moderate mental retardation and other developmental disabilities which is what it remains today.