[1] Pope Gregory XVI referred to it as "a new see" in a letter addressed to its first Archbishop, Antonio Nurigian sent on 3 February 1832.

When the patriarchal seat was moved to Beirut, Lebanon, the current archeparchy was erected on 15 October 1928.

[2][3] On 21 March 2015, it was made known that the Patriarch of Cilicia of the Armenians, with the consent of the Synod of Bishops of the Patriarchal Church, and after having informed the Holy See, had accepted the resignation of Archbishop Hovhannes Tcholakian.

Boghos Lévon Zékiyan was then elected Archbishop of Istanbul by the Synod of Bishops of the Patriarchal Church of Armenia.

On the 21 October 2024, The Synod of the Church of Cilicia of the Armenians has accepted the resignation from the pastoral care of the archeparchy of Istanbul of the Armenians, presented by Archbishop Lévon Boghos Zékiyan, and has appointed the Reverend Archpriest Vartan Kirakos Kazanjian, until now protosyncellus of the same archeparchy, as eparchial archbishop of Istanbul of the Armenians, Turkey.