The school serves the Armenian community east of Downtown Los Angeles, including those in Pico Rivera, Montebello, Whittier, Pasadena and Orange County.

Armenian current events, history, and literature are elements of the classes taught at this school.

Mesrobian, the first Armenian High School in the United States, has won dozens of academic and sportsmanship accolades since its opening in 1965.

[citation needed] In fall of 2024, Armenian Mesrobian School had their first Varsity Boys' Basketball Game of the Season against Montebello High in the brand new Gymnasium.

On January 23, 2025, Mesrobian saw twin brothers get local and national records in a blowout 119–25 win against Pasadena's Waverly High School with Nicholas Khatchikian scoring 102 points from 48/60 shooting before sitting out with two minutes left in the third quarter (a record previously set by former alumnus and current assistant coach, Tigran Gregorian) and Dylan Khatchikian recording a triple-double without scoring a single point with 35 assists, 15 rebounds, and 13 steals.