Located within the city's UNESCO World Heritage Site, the road has gained popularity in recent years for its rich cultural offerings and street art.

Notably, Armenian Street was also the site of Sun Yat-sen's Penang conference, which ultimately contributed to the downfall of the Qing Empire in 1911.

Concurrently, Armenian Street became notorious for Chinese triad activities, with the Hokkien-dominated Khian Teik Society establishing itself along the road.

As a result, Armenian Street witnessed heavy fighting during the 1867 Penang Riots, where the British authorities, reinforced with sepoys, built blockades and used force to quell the turf war between rival Chinese and Malay secret societies.

In 1910, Sun Yat-sen chaired the Penang conference within a townhouse at Armenian Street, during which he managed to raise $8,000 for revolutionary activities in China against the ruling Qing dynasty.