Tsamere has acted in several films, including the short Being Homer Simpson with Philippe Peythieu and Véronique Augereau, and Fonzy, a 2013 adaptation of Starbuck.

[8] His father was a general in the French Air Force[9] who was awarded the Legion of Honour,[10] and his mother a housewife, whom he has described as "the best in her domain".

However, he realised that he "could no longer live without the stage",[e][13] and on the advice of his friend Arnaud Joyet and Déclic Théâtre co-founder Alain Degois, quit his job and launched his career as a comedian.

[2] He began writing his first one-man show in 2002 with his friend Arnaud Joyet, inspired by a videotape of comedian François Rollin.

[2] The show, entitled Réflexions profondes sur pas mal de trucs[16] (Profound reflections on quite a few things), played on theatrical "flops", a form of humour that Tsamere said "can seem easy [but] is not when you really start to work on it".

Written in 2007,[17] it stars Tsamere as an economics teacher named Patrice Valenton, performing as part of a promise made to a friend who died in a car accident.

[2] Tsamere's third show, Confidences sur pas mal de trucs plus ou moins confidentiels (Secrets about quite a few more or less confidential things), also written with Rollin and Joyet, was performed on tour throughout France from November 2014, and at Le Splendid from January 2015.

[28] In 2005, with the help of Frédéric Testot, whom he met at a Puy-Saint-Vincent comedy festival, Tsamere got the job of presenting the weather forecast in Le Grand Journal on Canal+.

He was given the role of Captain Sport Extrême in Astier's comedy science fiction programme, Hero Corp, which is broadcast on France 4.

"[o][7] In 2010 he participated in the sketch comedy talent show On n'demande qu'à en rire, created and presented by Laurent Ruquier and broadcast on France 2.

[37] When the show returned for its fourth season, he acted as patron (parrain) during the first week, and could save and work with eliminated candidates.

[38] In September 2011, Tsamere appeared with On n'demande qu'à en rire colleague Jérémy Ferrari in two editions of Ruquier's late-night talk show On n'est pas couché—however, in what would have been their third week, they decided to quit the show as they thought that "our duo was not the right formula to succeed Jonathan [Lambert, their predecessor]",[q] as well as to concentrate on their "solo projects".

[r][39] From October 2012 to January 2013, Tsamere took part in the ONDAR Show, a spin-off of On n'demande qu'à en rire in which its best comedians performed without judges in a format similar to American entertainment.

[45] Three weeks later, TMC announced that Canapé Quiz had been cancelled and new episodes were to be moved to a later timeslot because of low viewing figures—10 days after its launch, it failed to pass 100,000 viewers.

[2][53] In the same year, he appeared in Pascale Pouzadoux's La Croisière, and in the short films Le Métro (directed by Dianeïa Schaefer)[54] and Deal (Wilfried Méance).

[58] Tsamere has written several columns about sport for the newspaper Le Monde,[59] on topics such as golfer Tiger Woods,[60] the cyclists Chris Froome and Lance Armstrong in the Tour de France,[61] and the French football league Ligue 1.

[62] In July 2015, an article he wrote entitled "And then along came Sky and ruined everything",[v] which accused Froome of doping, was cited by BBC News's Paris correspondent Hugh Schofield as an example of the hostility of the French press towards the cyclist.

[66] On his website, Tsamere provides a link to that of François Rollin, as well as to that of English comedian Ricky Gervais, whom he calls "my absolute master".

[68][69] Tsamere is a cycling enthusiast and a fan of association football;[59] he called the latter "My first great love to which I have remained faithful for so many years".

[72] Tsamere's favourite television programme is the Belgian documentary series Strip-Tease,[67] and he describes himself as "a real TV addict".

[72] He has read Une Vie by Guy de Maupassant, which he described as "so beautiful",[ae][74] and the biography of Apple Inc. founder Steve Jobs, which he said is "the story of an incredible life".