Back in Venezuela he was appointed to head the newly created Special Directorate of Malariology within the Ministry of Health and Welfare, a position he held until 1950.

[2] Under the direction of Gabaldón, Venezuela became the first state which organized a nationwide campaign against malaria using DDT, which led to the first eradication of the disease in a large tropical area.

Once the headquarters of the National Division of Malaria in Maracay was established, Gabaldón carefully selected collaborators and as a team faced the serious problem of malaria in the country, by adopting a strategy that broke with the traditional schemes of the time, and it is still in full force, diligently preparing the staff and with defined methodologies according to the needs, accompanying the process of epidemiological research and disease control with antibacterial and antiparasitic measures.

His strategy for antimalarial effort, was based on practical experiences of sanitation and supply of antimalarial drugs, with deep knowledge of national geopolitics and contact with people, becoming a national project, which immediately started to give positive results, so that high rates of morbidity and mortality malaria that decimated the country in the era of the 1930s, by 1944 had decreased significantly and its control was seen as possible.

[6] He also discovered new species of malarial parasites and devoted himself to studying the mosquito Anopheles nuneztovari, action that catalyzed the recognition of educational needs and preparing managerial staff of the Ministry of Health, through the creation of the school that bears his name in Maracay, a deep and additional contribution.

[4] Between 1959 and 1964 President Rómulo Betancourt appointed him Minister of Health and Welfare and Gabaldón developed a management program influenced by his professional background grounded in medical and environmental sanitation activities throughout the country.

His vision on the need for training or preparation for an efficient work in the field of malariology is expressed in his book "A Health Policy" and the "Letters of the Minister" which allowed him to disclose monthly to all staff and the country their views; He gave priority to preventive medicine for which he created the Environmental sanitation sub-department in 1960.