In the episode, Federal Bureau of Investigation (FBI) agents track an escaped prisoner who is seeking revenge against one of their own.
As Winters and his fellow escapees are federal prisoners, the Los Angeles Police Department calls FBI Special Agents David Sinclair (Alimi Ballard) and Nikki Betancourt (Sophina Brown) to the scene of an abandoned car and hands the FBI agents a rope made from dental floss.
David explains to Nikki that, two years prior, Buck's wife, Crystal Hoyle, kidnapped fellow FBI Special Agent Megan Reeves (Diane Farr).
FBI Special Agent Liz Warner (Aya Sumika), who knew only about Megan's kidnapping and had learned about Don's actions from FBI Special Agent Colby Granger (Dylan Bruno), confronts Don about his actions.
Amita Ramanujan (Navi Rawat) and Larry Fleinhardt (Peter MacNicol), Charlie's friends and fellow FBI consultants.
At the FBI office, Charlie confronts Don, who is reviewing a tape of the Crystal Hoyle shooting.
Robin, who has been outside during Buck's arrest, enters the synagogue and finds Don leafing through a copy of the Tanakh.
[5] Morrow felt that a law enforcement officer finding purpose in his work through religion was a rarity on television.
[5] Series executive producer Ken Sanzel decided to use the storyline started in "When Worlds Collide"[7] as the springboard into Don's spiritual search.
[4] In the arc, Charlie lost his security clearance when he sent classified information overseas at the end of season four.
In "Jack of All Trades", Don worked with FBI Special Agent Roger Bloom (Henry Winkler), an agent who stole $10 million (USD) from various banks in order to catch a petty thief who stole $2000 (USD) from Bloom's sister.
He set the story against the escape of a prisoner, Buck Winters, portrayed by David Gallagher, who was interrogated by Don in "Two Daughters".
[4] In "Two Daughters", FBI Special Agent Megan Reeves (Diane Farr), one of Don's teammates, was kidnapped by Winters' wife, Crystal Hoyle (Kim Dickens).