Zuokas participated in Valdas Adamkus's campaign during the 1997–98 presidential election as a member of its electoral committee, and joined the Liberal Union of Lithuania in 1999.

Before the municipal election of 2011, British actor Jeremy Irons expressed his support for Artūras Zuokas and invited people to vote for him in a short video about his experience in Vilnius.

Zuokas remained chairman of the party until 2009, when he was embroiled in a corruption scandal regarding the organization of European Capital of Culture activities in Vilnius in 2009.

[14] On 3 February 2024, Zuokas was elected as its chairman after its previous leader, Remigijus Žemaitaitis, was expelled from the party due to his antisemitic comments.

Using money received from the company, the "subscriber" allegedly attempted to bribe member of the Liberal Union Vilmantas Drėma to vote in favor of Zuokas, and also threatened the politician that he may be found "swimming in the Neris with an engorged belly" if he refused.

[17] On 20 March 2008, Zuokas was fined 12,500 litas for attempting to bribe a city council member, and the verdict was upheld by the Supreme Court after an appeal.

[22] Zuokas' management of the committee was characterized by lack of transparency, inflated expenses and contract prices, and several members of the city council called for his removal.

[25] Zuokas lives in Užupis,[26] a neighbourhood in Vilnius known for its bohemian and laissez-faire atmosphere, which has been compared to Montmartre in Paris and to Freetown Christiania in Copenhagen.

[27] On 1 April 1997, the district declared independence, calling itself the Republic of Užupis, and adopted a flag, constitution, an anthem, and a self-declared president - Romas Lileikis, a poet, a musician, and a film director.

The stunt was performed in cooperation with a bucket-list show aired on Swedish TV6, and the hosts Erik Ekstrand and Mackan Edlund sat in the back of the armored vehicle.

[29] Later that year he was awarded an Ig Nobel Peace Prize for "demonstrating that the problem of illegally parked luxury cars can be solved by running over them with a tank".

He proposed to name the island Dausuva, referring to the geopolitical concept of a "reserve Lithuania" created by interwar geographer and political thinker Kazys Pakštas.

[34] In 2023, Zuokas revealed that he has been collecting DNA samples of Lithuanian and worldwide celebrities for two decades - his collection includes samples of President of Lithuania Valdas Adamkus, John Malkovich, Daniel Libeskind, Steven Tyler, Violeta Urmana, Antanas Sutkus, Antanas Mockus and the Dalai Lama.

The Junior Chamber International recognized Zuokas for his administrative achievements by naming him one of the "Ten Outstanding Young Persons in the World" in 2002.