[citation needed] In the early 2000s, Pebdani began appearing on television shows such as The Shield, Ugly Betty, and House.
From 2005 onwards, she has had the recurring role of Artemis, the foul-mouthed friend of Sweet Dee, in the FX comedy series It's Always Sunny in Philadelphia.
[1] Pebdani has had guest starring roles on How I Met Your Mother, Modern Family, Raising Hope, Garfunkel and Oates, Brooklyn Nine-Nine, Hot in Cleveland, and House of Lies.
[1][3] Her character is the owner of a diet pill company for which Virginia Johnson works as a salesperson for part of the season.
In 2015, Pebdani joined the cast of Shonda Rhimes's political drama Scandal as Susan Ross, the new Vice President of the United States.