[5] It is native to Russia, Japan, and northern North America (from Alaska, east as far as Nunavut and south to Nevada).

[5] In experiments, simulated acid rain droplets were neutralized by the leaves of the plant, possibly due to the presence of various cations such as calcium.

It tolerates a range of soil pH and can grow on waste land made toxic by mining operations.

Artemisia tilesii has a number of historical uses in the traditional medicine systems of Alaska Native peoples.

It has been used to treat fever, infection, tumors, arthritis and other joint pains, bleeding, congestion, and tuberculosis, and as a laxative and general tonic.