The Asboe-Hansen sign (also known as "indirect Nikolsky sign'"[1] or "Nikolsky II sign"[1]) refers to the extension of a large blister to adjacent unblistered skin when pressure is put on the top of it.
[2][3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions.
[4] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
[5] It is considered an indirect diagnostic tool in toxic epidermal necrolysis (TEN).
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