This dicotyledonous, perennial plant was placed on the endangered species list by the state of Florida to protect this rare milkweed.

The leaves of Asclepias curtissii are large, elliptical, and dark green in color and usually have a noticeable undulating edge.

The sap of Asclepias curtissii contains cardenolides which are toxic to vertebrates in high quantities.

Curtiss's milkweed has a very high tolerance for soil disturbance, often being found along the edges of fire lanes and sand roads.

These insects include skipper butterflies and hairstreaks, which were found in abundance on the flowers of Asclepias curtissii.