It was released by Business Music and El Cartel Records as a single on May 11, 2018, for digital download and streaming.

An official remix for the song was released with the participation of Puerto Rican singers Daddy Yankee, Ozuna and Anuel AA on October 31, 2018.

In Spain, it debuted at number 64 on the issue dated June 8, 2018, before reaching the 12th position at its 22nd week on the chart.

On October 31, 2018, an official remix version of the song featuring Puerto Rican singers Daddy Yankee, Ozuna and Anuel AA was released by Business Music and Duars Entertainment and was made available worldwide as a single.

In the United States, "Asesina (remix)" appeared at number 13 on the Bubbling Under Hot 100 chart on the issue dated December 1, 2018.