[6] During his time at The Register, Vance covered companies such as IBM, HP, Intel, and Dell, and also wrote about a wide range of technology topics, including robots, Segway scooters, and the R programming language.

Vance hosted an audio podcast called Semi-Coherent Computing from 2007–2008,[10] in which he discussed enterprise computing topics such as data center cooling and blade servers, and interviewed guests including chip pioneer David Ditzel of Transmeta, Sun Microsystems, and Bell Labs.

[11] In 2015, Vance started writing, producing and hosting the "Hello World" video series for Bloomberg, focusing on the tech scene in various countries.

[18][19] At the beginning of 2025, Vance left Bloomberg to found Core Memory, a new digital media company focused on science and technology.

[20] Core Memory has a YouTube show, a podcast, and a Substack newsletter, but also aims to produce production-quality documentaries, the first of which is on brain-computer interfaces and was in production as of January, 2025.