During his tenure as Justice of Supreme Court he was part of the benches that disqualified two prime ministers Yousuf Raza Gillani and Nawaz Sharif.

During his tenure as Chief Justice, he nullified the Imran Khan government's decision to extend Qamar Javed Bajwa as Chief of Army Staff (COAS) for another three-year term and directed the government to put the tenure into law in under six months while giving the temporary extension of six months to Bajwa as COAS.

[5] Asif Saeed was born in 1954 in Dera Ghazi Khan, West Punjab, into a Punjabi Baloch Khosa family belonging.

When General Pervez Musharraf declared a state of emergency in November 2007, suspending the constitution and demanding the judges of the superior judiciary retake their oath under the Provisional Constitutional Order (PCO), Justice Khosa like then-Chief Justice Iftikhar Muhammad Chaudhry, and many other senior judges, refused to retake the oath.

In that case Supreme Court gave its judgement that had an additional attachment of Justice Khosa's extraordinary six-page note that became the subject of headlines in May 2012.

[9] He also headed the larger bench of the Supreme Court that was hearing the "Panama Case"[10][11] related to the alleged money laundering and off-shore illegal investment by former Prime Minister Nawaz Sharif and his family.

The final verdict issued by the larger bench on the "Panama Case" against Prime Minister Nawaz Sharif and his family has proposed a JIT within 60 days.

1 namely Mian Muhammad Nawaz Sharif from being a member of the Majlis-e-Shoora (Parliament) with effect from the date of announcement of the present judgment.