Asifabad was ruled by many dynasties like the Kakatiyas, Mauryas, Satavahanas, Chalukyas, Qutub Shahis & Asaf Jahis, Gond rajas.

In 1913, it was made as headquarters of the district prior to the status being lost to Adilabad in 1941.

Due to geographical proximity with Maharashtra, Gondi, Marathi is also widely spoken and understood.

Asifabad is connected to cities and surrounding villages in Telangana by the Telangana State Road Transport Corporation bus depot.The Nizam State Railways - Road Transport Division established the First bus depot in Asifabad.

The town is served by Asifabad Road [ASAF] railway station which is located 19 km away at Rebbena.