[1] Separated from her birth parents at a very young age, a blind girl named Fatima grows up under the protective wing of Mother Ben, an old gay man under the control of a criminal syndicate.

She is the daughter of a mortal man and a manananggal, a traditional demoness that separates at the midsection so the upper half can fly at night to feed on blood.

As Fatima reaches the age of seven, the search for her intensifies as witches, centaurs, mermaids and other malignant creatures join forces to prevent the girl from fulfilling the prophecy.

[2] Originally created/conceptualized by writer and director, Jun Lana for GMA Network, Aso ni San Roque is a drama-fantasy-adventure serial lies in the old "battle between good and evil" plot.

The series also highlights Pinoy mythology by putting aswang, manananggal, tikbalang, bruha and sirena as part [villains] of the story.

It headed by Queen Anaira, an evil mermaid which portrayed by Gwen Zamora; and the Aswang ng Apoy or the fire-powered witches ruled by Bulan, played by Angelika dela Cruz.

Rey, who rose in stardom after the successful drama series[15] Munting Heredera, felt overwhelmed with the network's support for her career and at the same time, excited for the role assigned on her.

[21] In one of her interviews, Reyes said that it's her first time to play a mother role on TV but she doesn't mind doing it as long as the story is good and the character, as well.

The dark forces or the main antagonists of the story are portrayed by Angelika dela Cruz, Gardo Versoza, Gwen Zamora and Paolo Contis.