Asquith is located 26 km north-west of the Sydney central business district, in the local government area of Hornsby Shire.

Asquith railway station opened on 1 November 1915, in conjunction with land released by R. Halloran & Company.

[3] Wrigley's Chewing Gum opened its first Australian office in 1961 in Asquith, and continues to operate from the same site.

[4] In December 2019, during Black Summer, a series of bushfires reached Asquith, causing significant suburban property damage, leading to widespread smoke and air quality issues in the Sydney area.

Asquith railway station is on the T9 Northern and T1 North Shore and Central Coast & Newcastle Lines.