At the request of Pope Pius X, a group of anglophone Assumption Sisters returned to Manila in 1904; the Philippine Islands were by then already under American colonial rule.

It was considered a school for the alta de sociedad (high society) and there was no other value more emphasised than the French term noblesse oblige: “To whom much is given, much will be required.” The school was once at the corner of Calle Herran and Calle Dakota (now known as Pedro Gil and Adriatico, respectively), beside the old Padre Faura campus of the all-boys' Ateneo de Manila, where the brothers of Assumptionistas often studied.

Neo-Gothic in design, the chapel featured arched, stained-glass windows and a comparatively small Gothic main altar.

In the afternoons, the students with lacy white mantillas on their heads, filled the chapel for common adoration, ending the day with singing the Tantum Ergo.

Students wore the distinct Assumption uniform of a tartan skirt (the fabric of which was supposedly first imported from France), sailor-collared shirts and a pin with a gold-coloured school seal.

The lace-filled immaculately white uniforms called "gala dress" were reserved for more formal occasions such as Mass and Graduation Rites.

Letters are distinctly long with sharp elongated points, it is a precise cursive, with flourished majuscules and jagged tails.

The school then expanded to its San Lorenzo, Makati campus, welcoming 180 students into its preparatory and elementary levels in June 1958.

The Grade School finally resettled as Assumption Antipolo along Sumulong Highway on 11 September 1974, with the Preschool staying in San Lorenzo.

The majority of its schools, campus ministries, and community development works are now among farmers, tribal minorities, and the urban poor.