Danish film historian Morten Piil described Villaume's appeal as a combination of "warm mother figure, romantic heroine and innocent erotic dream girl.
She attended the drama school at the Odense Theater from 1939 to 1941, and made her debut on stage there in the play Under Krigen (English: In The War).
She enjoyed success as a stage actress during the next six years, however she applied to return to the drama school at the Det Kongelige Teater (Royal Danish Theatre) in 1947.
"[2] She debuted at the Royal Danish Theatre in the role of Stine Isenkræmmer in Barselsstuen and from July 1949 Villaume was permanently employed there.
For her first leading role, as the beautiful baker's daughter in the 1950 film Susanne, Villaume was awarded the Bodil for Best Actress.