According to the National Archive[citation needed], a royal grant was issued to Martin Enriquez Visorrey in 1578 to establish the Spanish settlement.

Finally, because of a viceregal decision, the lands were given to the family of Mariano Francisco which settled here and founded the modern town.

Approximately 1 kilometer from the east part of the town, it is located in the Cerro Del Mosquito, an uninhabited area in which there has been found many prehistoric artifacts such as pottery, carved stones, and jade.

Every neighborhood of the town has its own religious idol, so when is time to prepare the festivity, a different person is chosen every year to organize the event.

In Cacalotepec every family visits their relatives graves and then prepare an ofrenda in which they offer to their loved ones a variety of traditional foods such as mole, tamales, mescal, chocolate, and bread, according to what the dead ancestor enjoyed while they were living.