[1] Beginning with UAAP Season 84 in May 2022, Ateneo de Manila University decided to unify student-athletes and varsity teams under the "Blue Eagles" moniker moving forward, regardless of sport, gender, or age group.

[12][13] When Ateneo and La Salle transferred to the UAAP in 1978 and 1986 respectively, they naturally continued their fierce battles and innate animosity against each other on and off-court, and the sports press began to recognize the rivalry.

[17] The games then moved to the pre-war Rizal Memorial Coliseum to accommodate bigger crowds, and at one point, the venues included the Ateneo Loyola Center, the Cuneta Astrodome, and the PhilSports Arena.

In terms of total collegiate and high school basketball titles won in the NCAA and UAAP, Ateneo leads La Salle, 58–28.

In 2004, La Salle and Ateneo finished the elimination round tied for second place, so a playoff game was played to determine which team gets the twice-to-beat advantage.

Chris Tiu passed the ball to Nonoy Baclao who scored a three-pointer to cut the lead to two, but JVee Casio converted both of his free-throws with 4 seconds left to punch La Salle's ticket to the Finals.

A few days prior to the Final 4 match between Ateneo and La Salle, the Blue Eagle's patron, Manny Pangilinan, announced that he would be pulling out his support from the school.

The entry of Perasol, who was rumored to be tapped as team consultant of the UP Fighting Maroons prior to his appointment as Ateneo head coach, also heralded the return of Manny Pangilinan as the Blue Eagles' main patron.

Filipino-American forwards Jason Perkins and Matthew Salem became a part of team roster, which had to adjust to the loss of resident players Yutien Andrada, Mac Tallo, Alfonzo Gotladera and Papot Paredes.

During their first round meeting at the Mall of Asia Arena on July 7, 2013, the Green Archers, banking on the heroics of combo guard Almond Vosotros and center Arnold Van Opstal, defeated the Blue Eagles, 82–73, resulting to Ateneo's third straight loss to start the season.

[76][77] The UAAP Board acted on UE's request for an inquiry, ordering Perasol to serve his one-game suspension during Ateneo's September 18, 2013 game against the UST Growling Tigers.

[78][79] Ateneo, with Perasol serving his one-game suspension, was eventually defeated by UST, 74–82, causing the Blue Eagles to not only be dethroned as UAAP Men's Basketball Champions after five straight seasons but to also miss Final Four contention for the first time since 1998.

Due to having the highest quotient, NU took the Number One spot with twice-to-beat advantage and faced UST in the Final Four, with the Growling Tigers defeating the Bulldogs in two games.

In the Final Four matches, La Salle went on to defeat the Adamson Soaring Falcons, while the Blue Eagles lost the first game to the FEU Tamaraws, their second loss of the season.

[94][95] During the resumption of the UAAP Season 84 in 2022, however, both Ateneo and La Salle lost to the University of the Philippines Fighting Maroons in the men's basketball post-season rounds.

As a result, this marked the first time in UAAP history that an eventual champion team has defeated both Ateneo and La Salle, as well as win multiple overtime games in the championship series, in the post-season rounds in men's basketball in any single season.

[108][109] UP and Ateneo eventually ousted NU and Adamson, respectively, en route to their second consecutive (and third overall) joint UAAP men's basketball championship series appearance.

[135] La Salle and UP defeated the Adamson Soaring Falcons and UST Golden Tigers, respectively, for their second consecutive and overall UAAP Finals matchup.

The De La Salle Lady Spikers became the first volleyball team ever to automatically enter the UAAP Finals with a thrice-to-beat advantage after sweeping the elimination round.

The UAAP Season 75 marked the first time ever that the league's Final Four and championship volleyball matches were played at the Smart Araneta Coliseum and the Mall of Asia Arena.

The De La Salle Lady Spikers became the first volleyball team ever to enter the UAAP Finals with a thrice-to-beat advantage after sweeping the elimination round for a second overall season.

In Game Four, the Ateneo Lady Eagles swept the De La Salle Lady Spikers, 25–23, 26–24, 25–21, to deny La Salle's second overall four-peat championship bid and become the lowest-seeded volleyball team to ever win a UAAP volleyball championship title (Ateneo's maiden title) at the Mall of Asia Arena after a 21,314-strong audience.

On the other hand, the second-seeded De La Salle Lady Spikers suffered their first defeat from a non-Ateneo team in the tournament (since UST Tigresses' shocking five-set season-opening win against DLSU in Season 75) during Game One against the third-seeded NU Lady Bulldogs in the semifinals (in straight sets), but recovered in Game Two in four sets at the expense of then La Salle's team captain Victonara Galang's post-season injury (which sidelined her from playing for Season 77 Finals).

This marked the first time that the eventual UAAP women's volleyball champions overcame a finals series game deficit to win the title since Season 76.

Then-graduating team captains Cherry Ann Rondina of UST and Bea de Leon of Ateneo were hailed the Most Valuable Player (MVP) awards of the Season and Finals, respectively.

[202][203] La Salle would later on repeat the same victory against Ateneo in the first round of the eliminations in the post-pandemic resumption of the UAAP tournaments in 2022 to extend their head-to-head winning streak since their finals sweep in Season 79.

La Salle would later on grab the second seed and twice-to-beat advantage in the stepladder playoffs after National University advanced outright to the UAAP Finals, while fourth-seeded Ateneo ousted Adamson and UST in consecutive games to become the lowest-seeded Final Four team in UAAP women's volleyball history to complete a podium finish after setting up the only second Ateneo–La Salle semifinals series in the same division.

La Salle went on to sweep the NU Lady Bulldogs in the Finals and claim their twelfth UAAP women's volleyball title in their first joint back-to-back UAAP Finals appearance since the sixth consecutive (and most recent) Ateneo-La Salle matchup in the championship series in Season 79, spearheaded by Angel Anne Canino, who became the school's first ever collegiate (and, as of 2025, the league's only second consecutive women's and most recent overall) volleyball player to win Rookie of the Year and Season Most Valuable Player (MVP) awards, and tournament championship in the same year.

In 2006, Ateneo handed La Salle its first humiliating 10-run loss, 17–7, on Jonathan Sibal's 2-RBI single off pitcher Jeff Ardio which ended the game prematurely at the 8th inning (mercy rule).

"[252][253] During the collegiate games between both schools, televised coverage would occasionally flash famous and notable alumni from entertainment, politics, business, education, and other fields watching and cheering from the sidelines.