It is listed on the National Register of Historic Places as the Athens B & O Train Depot.

The Baltimore and Ohio Railroad (B&O) constructed the station building around 1890, replacing an older structure.

It was served by trains including the St. Louis–Jersey City Diplomat and National Limited, and later the Metropolitan.

The Shenandoah was discontinued on October 1, 1981; it was replaced by the Capitol Limited, which followed a different route west of Cumberland and did not serve Athens.

This article about a property in Athens County, Ohio on the National Register of Historic Places is a stub.