With all runners starting from a crouch position, in the middle of the straightaway, the only returning medalist from 1932, Phil Edwards, rushed to the lead.
For the second day in a row, the German home crowd was seeing two black North Americans leading a final after Jesse Owens and Ralph Metcalfe winning the 100 metres.
Along the home stretch, Kazimierz Kucharski came along the outside, with Brian MacCabe in tow, effectively boxing Woodruff on the rail.
Sensing the danger, Woodruff slowed, dropping to sixth place but giving himself free running room.
Heading into the final turn, Edwards again accelerated into the lead, but Woodruff stayed with him as both separated from Kucharski and Chuck Hornbostel.
With the trailers struggling, a path down the rail opened up for Mario Lanzi to run past them on the inside.