The men's 110 metres hurdles at the 1992 Summer Olympics in Barcelona, Spain took place on 2 and 3 August 1992.

[2] The maximum number of athletes per nation had been set at 3 since the 1930 Olympic Congress.

McKoy, the 1982 and 1986 Commonwealth champion, was the favorite, though both the United States and Great Britain teams were strong and deep.

The United States made its 21st appearance, most of any nation (having missed only the boycotted 1980 Games).

The competition used the four-round format previously used in 1960 and 1988, still using the eight-man semifinals and finals used since 1964.