The Men's 100 metres T54 event at the 2012 Summer Paralympics took place at the London Olympic Stadium on 1 and 2 September.

[1] The T54 category is for wheelchair athletes with no leg function, but near full arm function and reasonable to normal trunk function.

Typically this may be caused by a lower spinal cord injury or spinal cord birth defect.

Prior to the competition, the existing World and Paralympic records were as follows.

rule: first 2 in each heat (Q) plus the 2 fastest other times (q) qualified.