The men's 100 metres T54 event at the 2020 Summer Paralympics in Tokyo, took place on 1 September 2021.

The T54 category is for wheelchair athletes with no leg function, but near full arm function and reasonable to normal trunk function.

Typically this may be caused by a lower spinal cord injury or spinal cord birth defect.

Prior to the competition, the existing records were as follows:[1] Heat 1 took place on 1 September 2021, at 11:43:[2] Heat 2 took place on 1 September 2021, at 11:50:[3] Heat 3 took place on 1 September 2021, at 11:57:[4] The final took place on 1 September 2021, at 19:30:[5]