The women's 100 metres T63 event at the 2020 Summer Paralympics in Tokyo, took place on 4 September 2021.

Prior to the competition, the existing records were as follows:[1] Heat 1 took place on 4 September 2021, at 11:02:[2] Heat 2 took place on 4 September 2021, at 11:08:[3] The final took place on 4 September 2021, at 21:26:[4]