The women's 100 metres at the 2022 Commonwealth Games, as part of the athletics programme, was held at Alexander Stadium on 2 and 3 August 2022.

[1] The original fifth placed finisher in the final, Nzubechi Grace Nwokocha, was provisionally suspended for doping in September 2022[2] and subsequently disqualified by the Commonwealth Games Federation.

[3] Prior to this competition, the existing world and Games records were as follows: The schedule was as follows:[4] All times are British Summer Time (UTC+1) The first round consisted of seven heats.

The three fastest competitors per heat (plus three fastest non-automatic qualifiers) advanced to the semifinals.

The two fastest competitors per semi (plus two fastest non-automatic qualifiers) advanced to the final.