The women's 100 metres (T38) at the 2022 Commonwealth Games, as part of the athletics programme, took place in the Alexander Stadium on 2 August 2022.

Prior to this competition, the existing world and Games records were as follows: The schedule was as follows:[1] All times are British Summer Time (UTC+1) First 3 in each heat (Q) and the next 2 fastest (q) advance to the Final[2] Wind: Heat 1: +0.2 m/s, Heat 2: +0.6 m/s

The medals were determined in the final.

[3] Wind: +0.6m/s