The women's 100 metres hurdles at the 2022 Commonwealth Games, as part of the athletics programme, took place in the Alexander Stadium on 5 and 7 August 2022.

Prior to this competition, the existing world and Games records were as follows: The schedule was as follows:[1] All times are British Summer Time (UTC+1) The first round consisted of three heats.

The two fastest competitors per heat (plus two fastest non-automatic qualifiers) advanced to the final.

[2] Wind: Heat 1: +2.5 m/s, Heat 2: +2.0 m/s, Heat 3: +2.4 m/s The medals were determined in the final.

[3] Wind: -0.2 m/s