The women's 4 × 100 metres relay at the 2022 Commonwealth Games, as part of the athletics programme, is taking place at the Alexander Stadium on 6 August & 7 August 2022.

On 14 July 2023, it was confirmed[1] that the Nigerian team had been disqualified for an anti-doping infringement.

As a result, England were promoted to gold, Jamaica to silver and Australia to bronze.

Prior to this competition, the existing world and Games records were as follows: The schedule was as follows:[2] The first three in each heat (Q) and the next two fastest (q) qualified for the final.

[3] The medals were determined in the final.