The women's 4 × 400 metres relay at the 2022 Commonwealth Games, as part of the athletics programme, took place in the Alexander Stadium on 7 August 2022.

Prior to this competition, the existing world and Games records were as follows: The schedule was as follows:[1] All times are British Summer Time (UTC+1) The medals were determined in the final.

[2] Although England beat Canada in a photo-finish by 0.01 second, it was found that England's Jodie Williams had intruded into an inner lane during the handover from Victoria Ohuruogu, and the gold was awarded to Canada, which was only revealed after England had already run a victory lap.

[3] (3:25.83)