She was best known for her portrayal of Motoko Kusanagi in the Ghost in the Shell film and franchise, and she also voiced Konan in Naruto, Caster in Fate/stay night, Lisa Lisa in JoJo's Bizarre Adventure, Chun-Li in Street Fighter III: 3rd Strike, Claudette in Queen's Blade, Karura in Utawarerumono, Bayonetta in the Bayonetta franchise, Hanami in Jujutsu Kaisen, and Kyrie Ushiromiya in Umineko no Naku Koro ni.

[4][3] After finding it unreasonable to work as an office lady until retirement, she decided to change careers after about six years with her employer, later recalling in a 2022 interview: "Even if it's not stable, if I can get a job that I like, it's rewarding and I can do it for the rest of my life".

[5][4][6] After failing to find a talent agency that would hire her, she was eventually invited to join Ezaki Production by manager Mitsue Ono.

[2] Although her parents initially disapproved of her voice acting career, they reconsidered after starring as the guest heroine in the 1993 Lupin the 3rd television special "Voyage to Danger".

[8] Outside of Ghost in the Shell, among her other voice acting roles in anime were Coffee in Cowboy Bebop, Margot Langer in Monster, Caster in Fate/stay night, Harumi Kiyama in A Certain Scientific Railgun, Konan in Naruto: Shippuden, Yuri Nikaido in The World God Only Knows, Lisa Lisa in JoJo's Bizarre Adventure, Reina in Yakuza Kiwami, and Hanami in Jujutsu Kaisen.

[9][2] Her video game roles included the titular protagonist of Bayonetta, Trish in Devil May Cry, Kainé in Nier, Lara Croft in Tomb Raider, Impa in The Legend of Zelda: Skyward Sword (2011), Gaby in Shin Megami Tensei IV (2013), Yennefer in The Witcher 3: Wild Hunt (2015), and Jerri in Persona 5 Tactica (2023), as well as Layla Hassan in Assassin's Creed and Chun-Li and Poison in Street Fighter.

[12] She then starred as Mary Sera in Case Closed, Flamme in Frieren, Rose in The Wrong Way to Use Healing Magic, and Ōmurasaki no Omae in Yatagarasu: The Raven Does Not Choose Its Master.

[3] Among the actresses she dubbed, she had a particularly strong attachment to Nicole Kidman, feeling "a great chemistry" with her and describing herself as "the one person in Japan who understands her acting the best.