The film's storyline concerns the plight of a wealthy heiress whose close encounter with an enormous alien in his round spacecraft causes her to grow into a giantess, complicating her marriage which is already troubled by a philandering husband.

Nancy Archer, a wealthy but highly troubled woman with a history of emotional instability and immoderate drinking, is driving on a road that night in an American desert.

Nancy escapes and runs back to town, but nobody believes her story due to her known drinking problem and a recent stay in a mental institution.

Her philandering husband, Harry Archer, is more interested in his latest girlfriend, town floozy Honey Parker.

He pretends to be the good husband in the hope that Nancy will "snap" and return to the "booby hatch," leaving him in control of her $50 million estate.

Nancy bargains with Harry, asking him to search the desert with her for the "flying satellite," agreeing to a voluntary return to the sanatorium if they find nothing.

Egged on by his mistress Honey, Harry plans to inject Nancy with a lethal dose of her sedative, but when he sneaks up to her room, he discovers that she has grown to giant size.

The sheriff and Jess, Nancy's faithful butler, track enormous footprints leading away from the estate to the alien sphere.

She tears off her mansion's roof and, clothed in a bikini-like arrangement of bed linens, heads to town to avenge herself on her unfaithful husband.

[12] In early 1979, Dimension Pictures announced that producer Steve Krantz was developing a 5-million-dollar remake with director Paul Morrissey.

In 1995, Fred Olen Ray produced a parody entitled Attack of the 60 Foot Centerfold, starring J.J. North and Tammy Parks.

Beyond the basic premise, the plot has little in common with the original film, being concerned with the side effects of a beauty-enhancing formula on two ambitious female models.

In early February 2024, Variety reported that Tim Burton and Gone Girl writer Gillian Flynn are developing a remake of Attack of the 50 Foot Woman for Warner Bros.[17] Attack of the 50 Foot Woman was released June 26, 2007 by Warner Bros. Home Video on region 1 DVD.