After noticing Dr. Steve Hardy (John Beradino), the Chief of Internal Medicine at General Hospital, Audrey stays in town and becomes a private nurse.

However, Mrs. Peggy Nelson, the woman taking care of the baby, realizes the plan and blackmails Audrey.

Tom reclaims baby Steve, who is renamed Tommy, forcing Audrey to resume their marriage.

Audrey feels gratitude towards Jim and marries him after he injuries his hands and fears he cannot operate again.

Audrey faces heartache as she still loves Steve and Jim turns to alcohol to deal with his injury.

Jeff ends up shooting himself, and when he is in the hospital, Terri tells Steve about a letter her mother, Helene, had told her about on her deathbed.

General Hospital is placed under quarantine, and when Steve begins to fall victim to the disease, Audrey tells Jeff the truth.

Steve and Audrey are happy to learn that Jeff's son Steven Lars Webber is still alive.

When Tom marries an African-American doctor, Simone Ravelle, Audrey fears her son's interracial marriage would not be accepted.

Audrey quickly recovers and testifies against Ryan at his trial, causing him to be committed to a mental institution.

Audrey is comforted by Gail Baldwin, Monica Quartermaine, and Kevin Collins during this difficult time.

Tom joins forces with Luke Spencer to bring the Cassadines down, but Audrey refuses to believe they are responsible.

Audrey stays extremely close with Elizabeth throughout the years and supports her through Lucky's return and brainwashing, Elizabeth's turbulent marriage to Ric Lansing, and her one-night stand with Zander Smith that results in Audrey's first great-grandchild Cameron.

On the 10,000th episode that aired on April 17, 2002, the staff throws a surprise party for Audrey honoring her 10,000th shift as a nurse.

Audrey is referenced in off-screen activities as continuing to live in Port Charles, frequently interacting with her grandchildren and great-grandchildren and enjoying her life as a retiree.

Audrey makes an appearance when she writes to her granddaughter, Elizabeth, for her upcoming wedding to Jake Doe/Jason Morgan.

[6][7] In the pre-Gloria Monty years of GH, Audrey was one of the leading characters of the show, and a 1971 storyline in which she was accused of murder sent General Hospital to the number one spot in the daytime ratings for the first time.