A love of Oriental languages and literature led him to exchange the University of Breslau for that of Berlin, in order to study to greater advantage, and there he was received into the house of the Orientalist Heinrich Friedrich von Diez.

In 1821 appeared his first work, Sufismus, sive theosophia Persarum pantheistica; following the same line of study he published Blütensammlung aus der morgenlandischen Mystik (1825) and Speculative Trinitätslehre des späteren Orients (1826).

His well-known essay on the nature and moral influence of heathenism (1822) was published by Neander, with high commendation, in his Denkwürdigkeiten; and his Commentary on the Epistle to the Romans (1824) secured him a foremost place amongst the most suggestive, if not the most accurate, Biblical interpreters of that time.

[2] Another work, soon translated into all the principal European languages, Die wahre Weihe des Zweiflers (1823), the outcome of his own religious history, obtained for him the permanent position of the modern Pietistic apologist of Evangelical Christianity.

In 1825, with the aid of the Prussian government, he visited the libraries of England and the Netherlands, and on his return was appointed (in 1826) professor ordinarius of theology at the University of Halle, the centre of German rationalism, where he afterwards became preacher and member of the supreme consistorial council of the Evangelical State Church in Prussia.

Karl Schwarz happily remarks that, as the English apologists of the 18th century were themselves infected with the poison of the deists whom they endeavoured to refute, so Tholuck absorbed some of the heresies of the rationalists whom he tried to overthrow.

Philip Schaff says, "Next to Neander, no German divine of the present century is more extensively known in the Protestant churches of ... America than Dr. Frederick Augustus Tholuck.