Augustus of Anhalt-Plötzkau (Dessau, 14 July 1575 – Plötzkau, 22 August 1653), was a German prince of the House of Ascania and ruler of the unified principality of Anhalt.
In 1586, after the death of his father, Augustus inherited Anhalt jointly with his half- and full brothers under the regency of the eldest, John George I.
After seventeen years of joint rule, the surviving brothers agreed to a formal division of their lands in 1603.
In 1611 he proposed publishing the two Rosicrucian manifestos together, but was unable to locate a copy of Confessio.
In Ansbach on 25 January 1618 Augustus married Sibylle (b. Laubach, 19 October 1590 - d. Plötzkau, 23 March 1659), daughter of John George I, Count of Solms-Laubach.