In addition to his work in Parliament, he was appointed secretary-general of The Republicans (LR) in 2019 after Christian Jacob was elected party leader, making him its third highest-ranking politician.

[14][15] On January 5, 2018, following French law against holding cumulative mandates, he resigned from his positions as mayor, president of the Community of Communes and as Regional Councilor.

Pradié beat Maurel in the second round with 51.3% of the vote, supported by strong results in rural parts of the district.

[3][17] His election made him the youngest MP in the history of Lot and came as a surprise in an area that has historically voted for left-wing parties.

[22] In November 2018, Pradié joined the Shadow cabinet of Laurent Wauquiez, in charge of disability issues and solidarity.

[24][25] In October 2018, Pradié defended a bill in the National Assembly in favor of better inclusion of handicapped children and adolescents in public schools.

This bill would have included better status for the students and their caregivers on campus and had widespread political support, but was rejected by La République En Marche!.

[28] At the Republicans’ national convention in December 2021, Pradié was part of the 11-member committee which oversaw the party's selection of its candidate for the 2022 presidential elections.

[33] In July 2019, Pradié voted against the French ratification of the European Union’s Comprehensive Economic and Trade Agreement (CETA) with Canada.