The former Chief Information Security Officer of Western Australia Police, Hai Tran, was appointed as the inaugural CEO in June 2020, ahead of its official launch on 6 July 2020.

[4] The centre was established in collaboration with the federal and South Australian Government, as well as industry partners including BAE Systems Australia and Optus; academic institutions including UniSA, Flinders University, The University of Adelaide and TAFE SA; South Australia's Office for Cyber Security; Commonwealth's Defence Science and Technology Group; and the independent (partly government-funded) organisations AustCyber and the Cyber Security Cooperative Research Centre.

[5] Before its opening, Aus3C had already launched a six-day pilot training course in collaboration with the University of Adelaide and aizoOn Australia, focused on digital forensics and incident response.

[7] An invite-only panel discussion was organised by the Australian Cyber Collaboration Centre in November 2022 with the topic of Australia's Security of Critical Infrastructure Act.

[10] Training is an essential component of its work, as cybercrime affects about 25 per cent of businesses, South Australia is developing its defence, space and other technology industries, and there is a shortage of skilled workers in cyber security.