[5][6] The Test series was the first time that the teams played for the Benaud–Qadir Trophy,[7] named after former international cricketers Richie Benaud and Abdul Qadir.

[34] After initial fears that some Australian players may opt out of the tour,[35] Australia named a full-strength Test squad on 8 February 2022.

[37][38] However, on 9 February 2022, that tour was abandoned after there were no managed isolation quarantine (MIQ) spots available for the Australian team.

[41] On 18 March 2022, the limited overs matches were moved from Rawalpindi to Lahore,[42] due to political tension in Islamabad.

[50] Prior to the start of the Test series, Mohammad Nawaz was ruled out of Pakistan's squad with a foot injury.

[58] On 20 March 2022, Zahid Mahmood replaced Mohammad Nawaz in Pakistan's ODI and T20I squads after not recovering from his foot injury.

[60] Ahead of the tour, Michael Neser was ruled out of the series and was replaced by Mark Steketee in the Australian Test team.

[64] Steve Smith was also ruled out of Australia's limited overs matches, due to an elbow problem,[65] and was replaced by Mitchell Swepson.

[68] Ashton Agar was ruled out of Australia's squad for the ODI matches after testing positive for COVID-19 with Matt Renshaw named as his replacement.