There was no fifty-dollar note released as part of the initial rollout of decimal currency in 1966, but inflation necessitated its introduction seven years later in 1973.

[2] The original paper fifty-dollar note released on Tuesday 9 October 1973, designed by Gordon Andrews, has a scientific theme.

On the back is a portrait of Sir Ian Clunies Ross, veterinary scientist and first chairman of the CSIRO, along with scenes from the Australian environment.

[9] The handwritten statement on the obverse of the note reads "As a full-blooded member of my race I think I may claim to be the first—but I hope, not the last—to produce an enduring record of our customs, beliefs and imaginings".

[3] There is also micro printing, in terms of "fifty dollars", and a shadow image of the Australian coat of arms when light is shown through it.

[13] The artwork on the note, incorporating the work of Kaurna/Ngarrindjeri artist Muriel van der Byl AM, retains the portraits of Cowan and Unaipon.