[1]: 52 The highway is a two-way divided six-lane road that starts at its junction in Barrio Canas with PR-500, near Avenida Baramaya (PR-9), next to Puente San Antonio,[1]: 251  and runs east until it meets PR-1 at Bulevar Miguel Pou.

Avenida Las Américas runs easterly from PR-500, intersecting with Ramal PR-2 (PR-2R) near Francisco Montaner Stadium and Juan Pachín Vicéns Auditorium, and passing Secretaría de Recreación y Deportes.

Additional businesses along its way are Café Rico and Centro del Sur Mall, both at Avenida Las Américas's intersection with PR-133, also known as Calle Comercio.

Although Avenida Las Américas ends at its intersection with PR-1, physically the roadway continues as a non-divided four-lane road called Avenida Emilio Fagot to intersect with PR-14 and, further north, to come to an end at a junction with PR-10 for access to points in northeast and north Puerto Rico, respectively.

The less transited western section of Avenida Las Américas experiences an hourly traffic flow upwards of 2400 vehicles.