The site of the assembly that touched off the revolution (the Buenos Aires Cabildo) was partially demolished in 1888 to make way for the avenue's entry into Plaza de Mayo.
The avenue's layout, built through existing urban blocks instead of via the widening of a parallel street, was designed by the municipal public works director, Juan Antonio Buschiazzo.
Buschiazzo was also commissioned to design a number of the buildings along the avenue (among them, City Hall) after Mayor Miguel Cané enacted strict architectural zoning laws for the area facing the new thoroughfare.
The recession caused by the Panic of 1890 led to delays and a rollback of many of the more ornate plans for the avenue, which was inaugurated on July 9, 1894 (the 78th anniversary of Independence).
The avenue itself underwent its only significant alteration in 1937, when one block were demolished to make way for the perpendicular Avenida 9 de Julio (the widest in the world).