Avenue B and C or B&C Colonia is a census-designated place (CDP)[2] and colonia[4] in Yuma County, Arizona, United States.

Areas that are part of Avenue B and C were first subdivided in the 1920s and 1930s.

[7] Avenue B and C first appeared on the 2010 U.S. Census as a census-designated place (CDP).

The racial and ethnic makeup of the population was 22.0% non-Hispanic white, 0.9% black or African American, 2.5% Native American, 0.3% Asian, 0.3% Pacific Islander, 0.1% non-Hispanic of some other race, 3.2% from two or more races and 74.7% Hispanic or Latino.

[9] Avenue B and C is served by the Crane Elementary School District and the Yuma Union High School District.