In an east-west axis, it connects the Gallieni Bridge to the Place du 11-Novembre 1918, it is then extended by the Avenue Jean Mermoz until the A43 autoroute.

[3] The avenue runs along the old École de santé des Armées, now named Centre Berthelot.

[1] Major axis of east-west traffic of the south of the city, its automobile attendance declined sharply since the construction of the tram line T2.

Motorists have now just two lanes (one-way east-west) along its entire length, the tram enjoying the other half of the roadway.

Notable monuments of this avenue are Centre Berthelot (hosting Center for the History of the Resistance and Deportation and Sciences Po Lyon), the Guillotière Cemetery, Le Comœdia cinema and the Jean Macé railway station.