Avenue D is the easternmost named avenue in the East Village neighborhood of Manhattan, New York City, east of Avenue C and west of the FDR Drive.

Avenues A, B, C and D are the origin of the name of the section of the East Village neighborhood through which they run, Alphabet City.

The street was created by the Commissioners' Plan of 1811, as one of 16 north–south streets specified as 100 feet (30 m) in width; they include 12 numbered avenues, and four (located east of First Avenue) designated by letter.

The M8 routes also travel on the avenue for short stretches.

[3] Among the structures along this avenue are: This article relating to roads and streets in New York City is a stub.