[6][2] When mentioning her and Nasuh Pasha's 1612 wedding, 17th-century historian Mustafa Naima refers to Ayşe as "the youngest of the princesses married in these day".

Ayşe and her sister, Fatma Sultan are extreme examples of this: they were married at least seven times, and entered into their last engagement at the ages of about 50 and 61, respectively.

[6] In 1622 her mother Kösem Sultan offered her hand in marriage to Hafız Ahmed Pasha (1564– 10 February 1632), Grand Vizier (1625–26, 1631–32).

[1] This old and ailing husband she strongly disliked, according to Venetian reports,[15] died – thus saving her from a unhappy life – during Murad's military campaign against Revan, which took place in the course of the Ottoman–Safavid War (1623–1639).

[17] In March[15] 1645 she married Voynuk Ahmed Pasha, beylerbey of Adana, Vizier, Admiral of the Fleet[1][15]12/22 June 1648 – 28 July 1649.

He took away their lands and jewels (presumably to award them to his Hasekis), and made them serve Hümaşah Sultan, the concubine he married, by standing at attention like servants while she ate and fetching and holding the soap, basin and pitcher of water with which she washed her hands.

[9] She apparently anxiously awaited her intended husband's arrival [25] – which he delayed for months [26] – for she dispatched several emissaries to bring him to the capital.

Her head servant, Mercan Ağa, finally succeeded in the task, and when Ibşir and his troops reached her palace in Üsküdar she treated him and the statesmen that had come to receive him to a great banquet,[9][15][27] "like a feast of Hatem Tay", according to Evliya Çelebi.

[9][15][4] In 1618, Ayşe Sultan had a water dispenser built between what is today Okçubaşı avenue and the tramway railway in Istanbul.