She was of Albanian origin, the daughter of Hasan Bey from the Jonima noble family.
Murat's wives and the only woman who received the title of Haseki Sultan directly when she married.
As per custom she was brought to the harem via the Ottoman slave trade, where she most likely appeared at around 1627 and soon became the sultan’s favorite concubine.
These changes were probably an aspect of Murad's dramatic assertion of personal control of government after nine years of his mother's regency.
In the TV series Muhteşem Yüzyıl: Kösem, Ayşe is portrayed by Turkish actress Leyla Feray.