It was established in 2018 by Dr. Mohammed Vizarat Rasool Khan, and is administered by Ayaan Educational Society.
[1][2] The institute is recognized by the National Medical Commission (NMC) and is affiliated with Kaloji Narayana Rao University of Health Sciences (KNRUHS) in Warangal.
[2][5] In response to the COVID-19 pandemic, the Telangana state government enlisted the support of 21 private medical college hospitals, including Ayaan Institute of Medical Sciences, permitted to treat patients in the state.
[8][9] The college operates its own bus service across the city for students and staff.
On August 28, 2023, a tragic accident involving one of the college buses occurred in Ramkote, Hyderabad, resulting in the death of a GHMC sanitation worker and injuries to four students on board.